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Benzodiazepines and Other Central Nervous System (CNS) Depressants Due to additive pharmacologic effect, the concomitant use of benzodiazepines and other CNS depressants, such as benzodiazepines and other sedative hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids and other opioids, including alcohol, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death

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Recognizing when symptoms indicate a need for a dosage adjustment prevents unnecessary discomfort

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