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Excessively consuming high-nutrient diets, such as red meat, eggs, and fish, not only directly affects energy metabolism, but also regulates the composition of intestinal flora, leading to an increase in plasma TMAO concentration

While polygenic risk scores (PRS) address part of this architecture by aggregating validated risk alleles from GWAS, the proposed workflow further considers the potential cumulative burden of variants typically deemed benign, aiming to bridge the gap between population-level risk estimation and individualized interpretation (Torkamani et al., 2018)

Founded in 1929, Ipsen built its commercial franchise almost entirely on two foundational peptide drugs: Somatuline (lanreotide), a long-acting somatostatin analogue for gastroenteropancreatic neuroendocrine tumours and acromegaly