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Across repeated weekly doses the drug accumulates to a steady state, so trough levels hold high enough to maintain therapeutic effect, without a cliff-like drop before the next dose

Back Molteni, M, Chen, E (30 Sept 2023) 'GLP-1 drugs are transforming diabetes, obesity and more

"For now I am back to exercise and willpower, but I look at my colleagues leaner but not hungrier and I hope that if science can do it for them, maybe one day it can help me, and everyone else." Charles Barkley said he lost 62 pounds on Mounjaro

[15] [16] Current UK prescribing information (SmPCs) for licensed GLP-1 receptor agonists does not list a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN2) as a contraindication, though individuals with such a history should discuss this with their clinician as a precautionary measure