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Real-world data link semaglutide, tirzepatide to improved heart failure outcomes Semaglutide and tirzepatide can help patients with heart failure with preserved ejection fraction (HFpEF) significantly improve their heart health, according to new data presented at ESC Congress 2025, the annual meeting of the European Society of Cardiology

Patients who struggle primarily with portion sizes and food cravings rather than metabolic insulin resistance often see strong results because semaglutide's appetite-suppressing effects remain potent across the dosing interval

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