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This pattern is consistent with a healthy-user bias, whereby individuals who are younger and generally healthier tend to experience more favorable outcomes regardless of treatment exposure

Neurologic aspects of cobalamin deficiency

Last but not least, it was shown recently that d-ribose drives non-enzymatic glycation of hemoglobin [188], thereby interfering with oxygen loading and unloading [182] and inducing erythrocyte damage and eryptosis [188]