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doi: 10.3389/fmolb.2025.1622186 Received 02 May 2025 Accepted 02 June 2025 Published 26 June 2025 Volume 12 - 2025 Edited by Roberta Marongiu, Cornell University, United States Reviewed by Larance Ronsard, Ragon Institute, United States Jorge Felipe Argenta Model, Federal University of Rio Grande do Sul, Brazil Updates Copyright 2025 Lizcano, Sanabria and Aviles

Because of the third pathway, retatrutide may cause: More noticeable early nausea Greater appetite reduction More rapid changes in digestion Some individuals tolerate tirzepatide vs retatrutide more easily, but it varies from person to person

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Lopez-Otin et al., 2013