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Of particular concern is the cumulative burden in vulnerable populations, including infants and children, where exposure sources are more difficult to eliminate or reduce

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Table 17: Daily Hunger Scores Change from Baseline at 1 Year in IMCIVREE-Treated Patients Aged 12 Years with Obesity due to POMC, PCSK1, or LEPR Deficiency in Trials 3 and 4 with Available Hunger Data Hunger scores generally worsened during the double-blind, placebo withdrawal period among those patients who had experienced an improvement from baseline, and scores improved when IMCIVREE was reinitiated

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