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Evidence increasingly demonstrates that obesity, metabolic syndrome and related comorbidities disrupt reproductive hormone balance, impair spermatogenesis and adversely affect fertility outcomes through complex endocrine, inflammatory, metabolic and epigenetic pathways
Note that the substantial weight loss from either GLP-1s or bariatric surgery is likely to have higher amounts of cost saving and QALY generation beyond the five years modeled in this study, as many of the complications of obesity are expressed later
APC has also demonstrated therapeutic potential in models of AD, ALS, and multiple sclerosis by reducing BBB breakdown, inflammatory responses, and neuronal damage [286,287,288,289,290]
Brugre JF, Borrel G, Gaci N, Tottey W, O'Toole PW, Malpuech-Brugre C
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