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It is then particularly important to tap into the mechanisms of active regulation of this process and to control it in the long term stage

Competitive binding between dynamic p53 transactivation subdomains to human MDM2 protein: implications for regulating the p53.MDM2/MDMX interaction

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Clinically significant vitamin B 12 deficiency and megaloblastic anemia are unlikely, unless these drug therapies are prolonged for two or more years, or if in addition, the person's dietary intake is below recommended levels