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While tirzepatide uses GIP to enhance insulin sensitivity and metabolic efficiency, retatrutide adds direct fat-burning stimulation through glucagon

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A change in the balance of these chemicals can change a persons mood or stress levels

Furthermore, some NGPs release extracellular vesicles and other bioactive metabolites that communicate with immune, epithelial, hepatic, and neural tissues, suggesting that their benefits may arise as much from postbiotic signaling as from mere colonization or competitive exclusion (539)